SYRE

Conviction 60HealthcareScan · Thu, Sep 24, 2026

Spyre Therapeutics, Inc. (SYRE) closed at $87.16 (-1.15%) on Sep 24, 2026. Price is below its 50-day and above its 200-day moving average. RSI(14) 38, RS Rating 99, -20.0% from its 52-week high, +185.0% year to date. Sector: Healthcare · PHARMACEUTICAL PREPARATIONS.

SYRE$87.16-1.15%

ResistanceSupportVol 14Insider sell

Vol MA14 1.39M

Jun 26Jul 15Aug 3Aug 19Sep 8Sep 24

Spyre Therapeutics, Inc.PHARMACEUTICAL PREPARATIONSwww.spyre.com ↗

Price87.16

Change-1.15%

Gap-0.76%

Rel volume2.19×

Avg volume1.38M

Avg $ vol124.23M

SMA 2089.86

SMA 5097.28

SMA 20066.01

Price vs 50-10.41%

Price vs 200+32.04%

MA stackmixed

50/200 cross—

Supertrenddown · 98.37

RSI (14)38

MACD hist0.08

MACD crossbull · 5d

Stoch %K / %D34 / 46

ADX (14)19

+DI / −DI15 / 27

RSI divergence—

MACD divergence—

ATR %5.22%

ADR %4.42%

52w high108.92

52w low15.61

From 52w high-19.98%

Above 52w low+458.33%

New 52w highNo

SqueezeOn · 2d

Bollinger width8.59%

%B0.15

Donchian pos34.06%

Donchian high95.19

Donchian low83.01

AVWAP (52w high)92.16

vs AVWAP high-5.43%

AVWAP (52w low)62.81

vs AVWAP low+38.76%

OBV trendFlat

Chaikin MF (20)0.12

Today vs 20d2.19×

Avg vol (14d)1.39M

Avg vol (20d)1.38M

Avg $ vol (20d)124.23M

Market cap7.68B

RS Rating99 / 99

RS 3m (vs SPY)-6.20%

RS 6m (vs SPY)+73.98%

RS line new highNo

Trend template6/8

Technical rank66.8

1 week-5.96%

1 month-18.82%

3 months-1.71%

6 months+90.79%

1 year+444.04%

YTD+185.01%

P/E-49.51

P/B6.98

P/S—

P/FCF-45.40

EPS-49.12

Div yield—

ROE-14.09%

ROA-13.23%

Debt/Eq—

Current18.53

EV/EBITDA-35.90

Gross margin—

Net margin—

Rev growth—

EPS growth25.39%

Price target122.73

Target upside40.82%

Analyst ratingBuy

Institutional115.10%

Ent. value7.52B

Revenue0

Net income-36.2M

Gross profit—

Free cash flow-169.25M

IndustryPHARMACEUTICAL PREPARATIONS

ExchangeNasdaq

Shares out86.84M

Employees112

ListedThu, Apr 7, 2016

Free float66.88M

Float %85.2%

Short interest11.86M

Days to cover9.7d

Short volume25.8%

Squeeze score75 / 100

Next earnings—

EPS forecast—

Last EPS vs est−$0.36 vs −$0.71

Last surprise+49.3% beat

Setup gradeB

Conviction60 / 100

Pattern quality—

Tech rank66.8 / 100

Group rank59 / 100

Status laneNo active setup

Setup direction—

Pattern family

Resistance110.16

Support88.36

Days since event—

Candle confirm—

Financials as of Tue, Jun 30, 2026 · quarterly.

Signal lifecycle

How this symbol has moved through the lanes across 60 scans — each scan is re-classified from that day's price, so gaps are days it dropped off the board entirely.

Setting up
Aug 5 – Aug 18
5 scans
→
Breaking out now
Aug 19
1 scan

Congress activity

Disclosed STOCK Act trades in SYRE

All disclosures →

No recent disclosed trades by Congress in SYRE. STOCK Act filings can lag the trade by up to 45 days.

Insider activity

SEC Form 4 transactions in SYRE · open-market 6 sells

Insider	Side	Shares	Value	Traded	Filed
Albers Jeffrey W. Director · Common Stock · 2026-08-07	Exercise	5K	$52K	2026-08-07	2026-08-10
Albers Jeffrey W. Director · Common Stock · 2026-08-07	Sell	5K	$522K	2026-08-07	2026-08-10
Albers Jeffrey W. Director · Common Stock · 2026-08-07	Sell	8K	$835K	2026-08-07	2026-08-10
Albers Jeffrey W. Director · Common Stock · 2026-08-07	Sell	10K	$1.0M	2026-08-07	2026-08-10
Albers Jeffrey W. Director · Stock Option (Right to Buy) · 2026-08-07	Exercise	5K	—	2026-08-07	2026-08-10
Burrows Scott L Chief Financial Officer · Common Stock · 2026-08-03	Exercise	7.5K	$109K	2026-08-03	2026-08-05
Burrows Scott L Chief Financial Officer · Common Stock · 2026-08-03	Sell	5.1K	$486K	2026-08-03	2026-08-05
Burrows Scott L Chief Financial Officer · Common Stock · 2026-08-03	Sell	2.3K	$221K	2026-08-03	2026-08-05
Burrows Scott L Chief Financial Officer · Common Stock · 2026-08-03	Sell	100	$10K	2026-08-03	2026-08-05
Burrows Scott L Chief Financial Officer · Stock Option (Right to Buy) · 2026-08-03	Exercise	7.5K	—	2026-08-03	2026-08-05

SEC filings

EDGAR filings in SYRE · 10 recent

EDGAR →

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